Cal announced before its game against Washington State on Saturday afternoon that starting center Chris Adcock is out for the season because of a knee injury.
The Bears also said senior safety Alex Logan has retired from football, effective immediately, because of recurring injuries.
The losses are the latest on a Cal team beset by injuries this season.
Adcock is the third starter on the offensive line to suffer an injury in the past three weeks. He suffered the injury during practice Wednesday, Cal said.
Coach Sonny Dykes, who has been open about health issues much of the season, did not provide an injury update during his Thursday post-practice session with reporters.
Adcock, a 6-foot-3, 305-pound junior, is a crucial player for the Bears, as the center in their Bear Raid offense calls the signals. He was expected to be replaced Saturday by senior Mark Brazinski, who was working with quarterback Jared Goff pregame.
Cal already is playing without starting right guard Matt Cochran, who had ankle surgery two weeks ago during the bye week. Right tackle Steven Moore sustained a head injury at Oregon last week and was questionable for the WSU game.
Logan, who started at free safety as recently as the Sept. 14 game vs. Ohio State, has struggled to stay healthy.
“The injuries I’ve incurred over the last year have greatly impacted my ability to play at a high level,” Logan said in a letter posted online by Rivals.com. “The last four injuries to my wrist, knee, foot and head have become a recurring nuisance and reminder that our bodies can only take so much before breaking down.”
Logan said he is on track to graduate.
Logan, who had an interception in the opening game against Northwestern, recently had dropped down the depth chart. Michael Lowe is listed as the starter.
Injuries have claimed four other players projected during fall camp as starters on defense: end Brennan Scarlett (hand), tackle Mustafa Jalil (knee), linebacker Nick Forbes (back) and strong safety Avery Sebastian (Achilles).
Defensive end Chris McCain was kicked off the team Sunday for conduct detrimental to the team.
Follow me on Twitter at twitter.com/JeffFaraudo