It will be interesting to see how Fox’s “Prison BreaK,” which launches its second season Aug. 21, plans to handle the defection of two actors who have moved on to other shows.

Both Patricia Wettig, who played the evil vice president on “Break,” and John Billingsley, who played her brother, have taken jobs with ABC. (”Brothers & Sisters” and “The Nine,” respectively). Wetting’s new series is being produced by her husband, Ken Olin.

Billingsley told us that his role was being recast, but Wettig said she didn’t know exactly what the producers are doing about her role and storyline.

“I don’t know how they are going to deal with it,” she said. “I had to make a choice. And it was kind of hard for me to choose against my husband and his good writing. So I’ll be on this one instead.”

We’ll check in with the “Prison Break” gang during Fox’s portion of the tour next Monday.